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The combination of trimethoprim and sulfamethoxazole acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.

Indications

Gastrointestinal, respiratory and urinary tract infections caused by trimethoprim and sulfamethoxazole sensitive bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.

Contra indications

Hypersensitivity to trimethoprim and/or sulphonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.

Side Effects

Anaemia, leucopenia and thrombocytopenia.

Administration and Dosage

For intramuscular administration: General: Twice daily 1 ml per 10 – 20 kg body weight for 3 – 5 days.

Withdrawal Time

- For meat : 12 days.
- For milk : 4 days.

Storage

Store below 25ºC, in a cool and dry place, and protect from light.

For Veterinary UseOnly , Keep out of reach of children