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Ceftiofur is a semisynthetic, third generation, broad-spectrum cephalosporin antibiotic, which is administered to cattle and swine for control of bacterial infections of the respiratory tract, with additional action against foot rot and acute metritis in cattle. It has a wide spectrum of activity against both Gram-positive and Gram-negative bacteria. It exerts its antibacterial action by inhibition of cell wall synthesis. Ceftiofur is mainly excreted in urine and faeces.

Indications

Cattle: Ceftionel-50 oily suspension is indicated for treatment of the following bacterial diseases: Bovine respiratory disease (BRD, shipping fever, pneumoniae) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni (Haemophilus somnus); acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus; Acute metritis (0 to 10 days post-partum) associated with bacterial organisms such as E.coli, Arcanobacterium pyogenes and Fusobacterium necrophorum.

Swine: Ceftionel-50 oily suspension is indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumoniae) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.

Contra-indications

Hypersensitivity to cephalosporins and other β-lactam antibiotics.

Administration to animals with a seriously impaired renal function.

Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.

Side Effects

Mild hypersensitivity reactions may occur occasionally at the injection site, which subside without further treatment.

Administration and Dosage

Cattle:

Bacterial respiratory infections: 1 ml per 50 kg body weight for 3 – 5 days, subcutaneously.

Acute interdigital necrobacillosis: 1 ml per 50 kg body weight for 3 days, subcutaneously.

Acute metritis (0 – 10 days post partum): 1 ml per 50 kg body weight for 5 days, subcutaneously.

Swine: Bacterial respiratory infections: 1 ml per 16 kg body weight for 3 days, intramuscularly.

Shake well before use and do not administer more than 15 ml in cattle per injection site and not more than 10 ml in swine. Successive injections should be administered at different sites.

Withdrawal Times

For meat: 21 days.

For milk: 3 days.

Storage

Store below 25ºC, in a cool and dry place, and protect from light.

For Veterinary UseOnly , Keep out of reach of children