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The combination of procaine penicillin G and dihydrostreptomycin acts additive and in some cases synergistic. Procaine penicillin G is a small-spectrum penicillin with a bactericidal action against mainly Gram-positive bacteria like Clostridium, Corynebacterium, Erysipelothrix, Listeria, penicillinase negative Staphylococcus and Streptococcus spp. Dihydrostreptomycin is an aminoglycoside with a bactericidal action against mainly Gram-negative bacteria like E. coli, Campylobacter, Klebsiella, Haemophilus, Pasteurella and Salmonella spp.

Indications

Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin and dihydrostreptomycin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.

Contra-indications

Hypersensitivity to penicillin, procaine and/or aminoglycosides.

Administration to animals with a seriously impaired renal function.

Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.

Side Effects

Administration of therapeutic dosages of procaine penicillin G can result in abortion in sows.

Ototoxity, neurotoxicity or nephrotoxicity.

Hypersensitivity reactions.

Administration and Dosage

For intramuscular administration:

Cattle : 1 ml per 20 kg body weight for 3 days.

Calves, goats, sheep and swine : 1 ml per 10 kg body weight for 3 days.

Shake well before use and do not administer more than 20 ml in cattle, more than 10 ml in swine and more than 5 ml in calves, sheep and goats per injection site.

Withdrawal Times

- For kidney : 45 days.

- For meat : 21 days.

For milk : 3 days.

Storage

Store below 25ºC, in a cool and dry place, and protect from light.

For Veterinary UseOnly , Keep out of reach of children