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The main pharmacological action of the active ingredient in Fluconix-340, nitroxinil, is fasciolicidal. The lethal action against Fasciola hepatica has been demonstrated in vitro and in vivo in laboratory animals, and in sheep and cattle. The mechanism of action is due to uncoupling of oxidative phosphorylation. It is also active against triclabendazole-resistant

F. hepatica.

Indications

Fluconix-340 is indicated for the treatment of fascioliasis (infestations of mature and immature Fasciola hepatica) in cattle and sheep. It is also effective, at the recommended dose rate, against adult and larval infestations of Haemonchus contortus in cattle and sheep and Haemonchus placei, Oesophagostomum radiatum and Bunostomum phlebotomum in cattle.

Contraindications

Do not use in animals with known hypersensitivity to the active ingredient.

Do not use in animals producing milk for human consumption.

Do not exceed stated dose.

Side Effects

Small swellings are occasionally observed at the injection site in cattle. These can be avoided by injecting the dose in two separate sites and massaging well to disperse the solution. No systemic ill effects are to be expected when animals (including pregnant cows and ewes) are treated at normal dosage.

Administration and Dosage

For subcutaneous injection. Ensure the injection does not enter subcutaneous muscle. Wear impermeable gloves to avoid staining and irritation of the skin. The standard dosage is 10 mg nitroxinil per kg of bodyweight.

Sheep: Administer according to the following doses scale:

14 – 20 kg 0.5 ml 41 – 55 kg 1.5 ml

21 – 30 kg 0.75 ml 56 – 75 kg 2.0 ml

31 – 40 kg 1.0 ml > 75 kg 2.5 ml

In outbreaks of fascioliasis each sheep in the flock should be injected immediately when the presence of the disease is recognised, repeating treatment as necessary throughout the period when infestation is occurring, at intervals of not less than one month.

Cattle: 1.5 ml of Fluconix-340 per 50 kg of bodyweight.

Both infected and in-contact animals should be treated, treatment being repeated as considered necessary, though not more frequently than once per month. Dairy cows should be treated at drying off (at least 28 days before calving).

Note: Do not use in animals producing milk for human consumption.

Withdrawal Times

- For meat:

Cattle : 60 days.

Sheep : 49 days.

Storage

Store below 25ºC, in a cool and dry place, and protect from light.

For Veterinary UseOnly , Keep out of reach of children